Chamber of Commerce Building, also known as the North Greenville College Building, is a historic office building located at Greenville, South Carolina. It was built in 1925, and is a ten-story rectangular brick sheathed steel frame building. The Chicago School style skyscraper consists of a two-story base with Neoclassical detailing, a seven-story shaft, and a roof story that features tall arched windows and a brick and stone frieze with transoms and stone panels.
It was added to the National Register of Historic Places in 1982.
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